Drug interactions
Cyclophosphamide + Meningococcal group b vaccine
Severity: Moderate
Cyclophosphamide and Meningococcal group b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide-induced immunosuppression may reduce the antibody response to the meningococcal B vaccine, leaving the patient with incomplete protection. The vaccine is non-live, so the issue is reduced efficacy rather than infection from the vaccine.
What this interaction means in plain words
Cyclophosphamide and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic suppression of lymphocyte function reduces vaccine immunogenicity.
What to do
Vaccinate before starting cyclophosphamide when possible, or after immune recovery. Consider checking response or giving additional doses in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Meningococcal group b vaccine?
MediHelp rates the interaction as moderate. Cyclophosphamide and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclophosphamide-induced immunosuppression may reduce the antibody response to the meningococcal B vaccine, leaving the patient with incomplete protection. The vaccine is non-live, so the issue is reduced efficacy rather than infection from the vaccine.
How serious is the interaction between Cyclophosphamide and Meningococcal group b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting cyclophosphamide when possible, or after immune recovery. Consider checking response or giving additional doses in high-risk patients.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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