Drug interactions
Cyclophosphamide + Olaparib
Severity: Major
Cyclophosphamide and Olaparib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib combined with DNA-damaging chemotherapy such as cyclophosphamide can potentiate and prolong myelosuppression. This increases the risk of anemia, neutropenia, thrombocytopenia and infection.
What this interaction means in plain words
Cyclophosphamide and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclophosphamide belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression from PARP inhibition combined with DNA alkylation damage.
What to do
Monitor complete blood counts frequently and reduce doses or delay cycles for cytopenias. Combine only under oncology supervision with a defined regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclophosphamide and Olaparib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclophosphamide
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Cyclophosphamide with Olaparib?
MediHelp rates the interaction as major. Cyclophosphamide and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olaparib combined with DNA-damaging chemotherapy such as cyclophosphamide can potentiate and prolong myelosuppression. This increases the risk of anemia, neutropenia, thrombocytopenia and infection.
How serious is the interaction between Cyclophosphamide and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce doses or delay cycles for cytopenias. Combine only under oncology supervision with a defined regimen.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
