Drug interactions
Cyclophosphamide + Streptozocin
Severity: Moderate
Cyclophosphamide and Streptozocin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause bone marrow suppression, so together they may deepen neutropenia, anemia and thrombocytopenia. Streptozocin also causes nephrotoxicity, which can complicate management of cyclophosphamide metabolites.
What this interaction means in plain words
Cyclophosphamide and Streptozocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppressive effects of two cytotoxic agents.
What to do
Monitor complete blood counts regularly and renal function, and adjust doses or delay cycles for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Streptozocin?
MediHelp rates the interaction as moderate. Cyclophosphamide and Streptozocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause bone marrow suppression, so together they may deepen neutropenia, anemia and thrombocytopenia. Streptozocin also causes nephrotoxicity, which can complicate management of cyclophosphamide metabolites.
How serious is the interaction between Cyclophosphamide and Streptozocin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and renal function, and adjust doses or delay cycles for significant cytopenias.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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