Drug interactions
Cycloserine + Ethionamide
Severity: Moderate
Cycloserine and Ethionamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neuropsychiatric adverse effects, and together they may increase the risk of dizziness, confusion, psychosis and seizures. They are commonly used together in multidrug-resistant tuberculosis regimens.
What this interaction means in plain words
Cycloserine and Ethionamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system toxicity.
What to do
Monitor mental status and seizure activity, and consider pyridoxine supplementation. Reduce the cycloserine dose or stop it if significant CNS toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cycloserine
Frequently asked questions
Can I take Cycloserine with Ethionamide?
MediHelp rates the interaction as moderate. Cycloserine and Ethionamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause neuropsychiatric adverse effects, and together they may increase the risk of dizziness, confusion, psychosis and seizures. They are commonly used together in multidrug-resistant tuberculosis regimens.
How serious is the interaction between Cycloserine and Ethionamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status and seizure activity, and consider pyridoxine supplementation. Reduce the cycloserine dose or stop it if significant CNS toxicity develops.
What other medicines interact with Cycloserine?
MediHelp also lists interactions of Cycloserine with, for example, Isoniazid, Sodium picosulfate / magnesium oxide / anhydrous citric acid. The full list is on the Cycloserine page.
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