Drug interactions
Cyclosporin + Dabrafenib
Severity: Moderate
Cyclosporin and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and other enzymes and may reduce cyclosporine exposure. Loss of immunosuppressive effect could cause graft rejection or poor disease control.
What this interaction means in plain words
Cyclosporin and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib-mediated induction of CYP3A4 increases cyclosporine clearance.
What to do
Monitor cyclosporine trough concentrations when starting or stopping dabrafenib and increase the dose as needed. Reduce the dose again after dabrafenib discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Cyclosporin with Dabrafenib?
MediHelp rates the interaction as moderate. Cyclosporin and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and other enzymes and may reduce cyclosporine exposure. Loss of immunosuppressive effect could cause graft rejection or poor disease control.
How serious is the interaction between Cyclosporin and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations when starting or stopping dabrafenib and increase the dose as needed. Reduce the dose again after dabrafenib discontinuation.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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