Drug interactions
Cyclosporin + Darifenacin
Severity: Moderate
Cyclosporin and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase darifenacin exposure and its anticholinergic effects such as dry mouth, constipation and blurred vision.
What this interaction means in plain words
Cyclosporin and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Darifenacin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 and possibly P-glycoprotein by cyclosporine, reducing darifenacin clearance.
What to do
Monitor for anticholinergic adverse effects and limit darifenacin to the lower dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Darifenacin
Frequently asked questions
Can I take Cyclosporin with Darifenacin?
MediHelp rates the interaction as moderate. Cyclosporin and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase darifenacin exposure and its anticholinergic effects such as dry mouth, constipation and blurred vision.
How serious is the interaction between Cyclosporin and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and limit darifenacin to the lower dose if needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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