Drug interactions
Cyclosporin + Elagolix
Severity: Contraindicated
Cyclosporin and Elagolix: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits OATP1B1 and substantially increases elagolix exposure, raising the risk of adverse effects such as bone loss, liver enzyme elevation and mood changes. Elagolix labeling prohibits use with strong OATP1B1 inhibitors such as cyclosporine.
What this interaction means in plain words
Cyclosporin and Elagolix are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclosporin belongs to Miscellaneous; Elagolix belongs to Musculoskeletal.
Why it happens
Cyclosporine inhibits OATP1B1-mediated hepatic uptake of elagolix, increasing its plasma concentration.
What to do
Do not coadminister; choose alternative endometriosis therapy while cyclosporine is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Elagolix
Frequently asked questions
Can I take Cyclosporin with Elagolix?
MediHelp rates the interaction as contraindicated. Cyclosporin and Elagolix are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine inhibits OATP1B1 and substantially increases elagolix exposure, raising the risk of adverse effects such as bone loss, liver enzyme elevation and mood changes. Elagolix labeling prohibits use with strong OATP1B1 inhibitors such as cyclosporine.
How serious is the interaction between Cyclosporin and Elagolix?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose alternative endometriosis therapy while cyclosporine is needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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