Drug interactions
Cyclosporin + Diazepam intranasal
Severity: Moderate
Cyclosporin and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may reduce diazepam clearance via CYP3A4 inhibition, increasing sedation and respiratory depression risk. Diazepam is also metabolized by CYP2C19, which limits the effect.
What this interaction means in plain words
Cyclosporin and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits CYP3A4-mediated diazepam metabolism.
What to do
Monitor for excess sedation and respiratory depression, particularly with repeated doses, and use the lowest effective diazepam dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Diazepam intranasal?
MediHelp rates the interaction as moderate. Cyclosporin and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may reduce diazepam clearance via CYP3A4 inhibition, increasing sedation and respiratory depression risk. Diazepam is also metabolized by CYP2C19, which limits the effect.
How serious is the interaction between Cyclosporin and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression, particularly with repeated doses, and use the lowest effective diazepam dose.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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