Drug interactions
Cyclosporin + Dihydroergotamine intranasal
Severity: Major
Cyclosporin and Dihydroergotamine intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may raise systemic dihydroergotamine levels through CYP3A4 inhibition, raising the risk of ergotism, with peripheral and cerebral vasospasm and ischemia.
What this interaction means in plain words
Cyclosporin and Dihydroergotamine intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated dihydroergotamine metabolism.
What to do
Avoid the combination and use a non-ergot migraine treatment. If it cannot be avoided, monitor closely for signs of vasospasm such as limb coldness, paresthesias and chest pain.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Dihydroergotamine intranasal?
MediHelp rates the interaction as major. Cyclosporin and Dihydroergotamine intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine may raise systemic dihydroergotamine levels through CYP3A4 inhibition, raising the risk of ergotism, with peripheral and cerebral vasospasm and ischemia.
How serious is the interaction between Cyclosporin and Dihydroergotamine intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-ergot migraine treatment. If it cannot be avoided, monitor closely for signs of vasospasm such as limb coldness, paresthesias and chest pain.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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