Drug interactions
Cyclosporin + Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine
Severity: Minor
Cyclosporin and Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin can diminish the antibody response to this inactivated combination vaccine. Because no live organisms are present, it does not cause vaccine-strain infection, and vaccination remains recommended.
What this interaction means in plain words
Cyclosporin and Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Calcineurin inhibition impairs T-cell-dependent antibody production against vaccine antigens.
What to do
Vaccinate according to the schedule, ideally before immunosuppression is intensified. Consider antibody testing and revaccination if the response may be inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine?
MediHelp rates the interaction as minor. Cyclosporin and Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporin can diminish the antibody response to this inactivated combination vaccine. Because no live organisms are present, it does not cause vaccine-strain infection, and vaccination remains recommended.
How serious is the interaction between Cyclosporin and Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate according to the schedule, ideally before immunosuppression is intensified. Consider antibody testing and revaccination if the response may be inadequate.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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