Drug interactions
Cyclosporin + Diphtheria and tetanus toxoids / acellular pertussis vaccine
Severity: Minor
Cyclosporin and Diphtheria and tetanus toxoids / acellular pertussis vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin may reduce the immune response to this inactivated combination vaccine, resulting in lower protection. The vaccine is non-live, so there is no risk of vaccine-derived infection and it should generally still be given.
What this interaction means in plain words
Cyclosporin and Diphtheria and tetanus toxoids / acellular pertussis vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Calcineurin inhibition dampens T-cell-dependent antibody responses to vaccine antigens.
What to do
Continue to follow the routine schedule rather than withholding the vaccine. Consider serologic checks where available and additional doses if the response is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Diphtheria and tetanus toxoids / acellular pertussis vaccine?
MediHelp rates the interaction as minor. Cyclosporin and Diphtheria and tetanus toxoids / acellular pertussis vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporin may reduce the immune response to this inactivated combination vaccine, resulting in lower protection. The vaccine is non-live, so there is no risk of vaccine-derived infection and it should generally still be given.
How serious is the interaction between Cyclosporin and Diphtheria and tetanus toxoids / acellular pertussis vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue to follow the routine schedule rather than withholding the vaccine. Consider serologic checks where available and additional doses if the response is poor.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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