Drug interactions
Cyclosporin + Doxorubicin liposomal
Severity: Major
Cyclosporin and Doxorubicin liposomal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can increase doxorubicin exposure and its toxicity, including myelosuppression and cardiotoxicity. Liposomal formulation may reduce but not remove the effect.
What this interaction means in plain words
Cyclosporin and Doxorubicin liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cyclosporine inhibits P-gp and CYP3A4 and may reduce doxorubicin clearance.
What to do
Monitor blood counts and cardiac function, and consider reducing the doxorubicin dose. Check cyclosporine levels, as myelosuppression may need adjustment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Doxorubicin liposomal?
MediHelp rates the interaction as major. Cyclosporin and Doxorubicin liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine can increase doxorubicin exposure and its toxicity, including myelosuppression and cardiotoxicity. Liposomal formulation may reduce but not remove the effect.
How serious is the interaction between Cyclosporin and Doxorubicin liposomal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and consider reducing the doxorubicin dose. Check cyclosporine levels, as myelosuppression may need adjustment.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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