Drug interactions
Cyclosporin + Elbasvir / grazoprevir
Severity: Contraindicated
Cyclosporin and Elbasvir / grazoprevir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine markedly raises grazoprevir and also increases elbasvir exposure, increasing the risk of hepatic transaminase elevation. The combination is contraindicated in labeling.
What this interaction means in plain words
Cyclosporin and Elbasvir / grazoprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Cyclosporine inhibits OATP1B1/3 hepatic uptake of grazoprevir, and may also inhibit CYP3A4.
What to do
Do not coadminister; select another HCV regimen without this interaction or defer treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Elbasvir / grazoprevir?
MediHelp rates the interaction as contraindicated. Cyclosporin and Elbasvir / grazoprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine markedly raises grazoprevir and also increases elbasvir exposure, increasing the risk of hepatic transaminase elevation. The combination is contraindicated in labeling.
How serious is the interaction between Cyclosporin and Elbasvir / grazoprevir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; select another HCV regimen without this interaction or defer treatment.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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