Drug interactions
Cyclosporin + Encorafenib
Severity: Major
Cyclosporin and Encorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can raise encorafenib concentrations through CYP3A4 inhibition. Increased exposure may worsen encorafenib toxicities including QT prolongation, dermatologic and ocular effects.
What this interaction means in plain words
Cyclosporin and Encorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Encorafenib belongs to Oncology.
Why it happens
Cyclosporine inhibits CYP3A4-mediated metabolism of encorafenib (and may inhibit P-gp efflux).
What to do
Avoid if possible. If unavoidable, reduce encorafenib dose by about half, monitor ECG and electrolytes, and restore the original dose after stopping cyclosporine for 3-5 half-lives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Cyclosporin with Encorafenib?
MediHelp rates the interaction as major. Cyclosporin and Encorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine can raise encorafenib concentrations through CYP3A4 inhibition. Increased exposure may worsen encorafenib toxicities including QT prolongation, dermatologic and ocular effects.
How serious is the interaction between Cyclosporin and Encorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce encorafenib dose by about half, monitor ECG and electrolytes, and restore the original dose after stopping cyclosporine for 3-5 half-lives.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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