Drug interactions
Cyclosporin + Estradiol vaginal
Severity: Minor
Cyclosporin and Estradiol vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic absorption from low-dose vaginal estradiol is small, so any rise in estradiol exposure from cyclosporine is unlikely to matter clinically.
What this interaction means in plain words
Cyclosporin and Estradiol vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cyclosporine may inhibit CYP3A4 metabolism of estradiol, with minimal systemic effect at vaginal doses.
What to do
No dose adjustment needed; be aware of estrogenic adverse effects such as breast tenderness or bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Estradiol vaginal?
MediHelp rates the interaction as minor. Cyclosporin and Estradiol vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic absorption from low-dose vaginal estradiol is small, so any rise in estradiol exposure from cyclosporine is unlikely to matter clinically.
How serious is the interaction between Cyclosporin and Estradiol vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed; be aware of estrogenic adverse effects such as breast tenderness or bleeding.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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