Drug interactions
Cyclosporin + Estropipate
Severity: Moderate
Cyclosporin and Estropipate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and P-glycoprotein and may increase estrogen exposure. This could heighten estrogenic adverse effects such as breast tenderness, fluid retention and thromboembolic risk.
What this interaction means in plain words
Cyclosporin and Estropipate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits CYP3A4-mediated metabolism and P-gp efflux of estrogens.
What to do
Monitor for estrogenic adverse effects and use the lowest effective estrogen dose. Reduce the estrogen dose if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Estropipate?
MediHelp rates the interaction as moderate. Cyclosporin and Estropipate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits CYP3A4 and P-glycoprotein and may increase estrogen exposure. This could heighten estrogenic adverse effects such as breast tenderness, fluid retention and thromboembolic risk.
How serious is the interaction between Cyclosporin and Estropipate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects and use the lowest effective estrogen dose. Reduce the estrogen dose if effects emerge.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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