Drug interactions
Cyclosporin + Ethotoin
Severity: Moderate
Cyclosporin and Ethotoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydantoin anticonvulsants such as phenytoin lower cyclosporine concentrations, and ethotoin may do the same. Subtherapeutic cyclosporine can lead to transplant rejection or loss of disease control.
What this interaction means in plain words
Cyclosporin and Ethotoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ethotoin is thought to induce CYP3A4 like other hydantoins, increasing cyclosporine metabolism; evidence for ethotoin specifically is limited.
What to do
Monitor cyclosporine trough levels and increase the dose as needed, or use a non-inducing anticonvulsant. Recheck levels after stopping ethotoin to avoid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Ethotoin?
MediHelp rates the interaction as moderate. Cyclosporin and Ethotoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydantoin anticonvulsants such as phenytoin lower cyclosporine concentrations, and ethotoin may do the same. Subtherapeutic cyclosporine can lead to transplant rejection or loss of disease control.
How serious is the interaction between Cyclosporin and Ethotoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and increase the dose as needed, or use a non-inducing anticonvulsant. Recheck levels after stopping ethotoin to avoid toxicity.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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