Drug interactions
Cyclosporin + Fenofibrate micronized
Severity: Moderate
Cyclosporin and Fenofibrate micronized: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates have been associated with raised serum creatinine and nephrotoxicity when given with cyclosporine. Cyclosporine concentrations may also change, and the combination may increase muscle toxicity risk.
What this interaction means in plain words
Cyclosporin and Fenofibrate micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Not well established; additive renal effects and possible altered cyclosporine disposition.
What to do
Monitor serum creatinine and cyclosporine trough levels after starting fenofibrate, and stop the fibrate if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Fenofibrate micronized?
MediHelp rates the interaction as moderate. Cyclosporin and Fenofibrate micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates have been associated with raised serum creatinine and nephrotoxicity when given with cyclosporine. Cyclosporine concentrations may also change, and the combination may increase muscle toxicity risk.
How serious is the interaction between Cyclosporin and Fenofibrate micronized?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and cyclosporine trough levels after starting fenofibrate, and stop the fibrate if renal function worsens.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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