Drug interactions
Cyclosporin + Fentanyl transdermal
Severity: Moderate
Cyclosporin and Fentanyl transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase fentanyl exposure through CYP3A4 inhibition. With a long-acting patch, this can cause delayed and prolonged sedation and respiratory depression.
What this interaction means in plain words
Cyclosporin and Fentanyl transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits CYP3A4, reducing fentanyl clearance.
What to do
Monitor for sedation and respiratory depression, especially after starting or stopping cyclosporine. Reduce the patch dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Fentanyl transdermal?
MediHelp rates the interaction as moderate. Cyclosporin and Fentanyl transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase fentanyl exposure through CYP3A4 inhibition. With a long-acting patch, this can cause delayed and prolonged sedation and respiratory depression.
How serious is the interaction between Cyclosporin and Fentanyl transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, especially after starting or stopping cyclosporine. Reduce the patch dose if needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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