Drug interactions
Cyclosporin + Fentanyl transmucosal
Severity: Moderate
Cyclosporin and Fentanyl transmucosal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may raise fentanyl concentrations through CYP3A4 inhibition. This can result in excessive sedation and respiratory depression.
What this interaction means in plain words
Cyclosporin and Fentanyl transmucosal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits CYP3A4, reducing fentanyl clearance.
What to do
Monitor for respiratory depression and sedation at frequent intervals. Lower the fentanyl dose if excess opioid effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporin and Fentanyl transmucosal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Fentanyl transmucosal?
MediHelp rates the interaction as moderate. Cyclosporin and Fentanyl transmucosal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may raise fentanyl concentrations through CYP3A4 inhibition. This can result in excessive sedation and respiratory depression.
How serious is the interaction between Cyclosporin and Fentanyl transmucosal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for respiratory depression and sedation at frequent intervals. Lower the fentanyl dose if excess opioid effects emerge.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
