Drug interactions
Cyclosporin + Fosamprenavir
Severity: Major
Cyclosporin and Fosamprenavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amprenavir, the active metabolite of fosamprenavir, inhibits CYP3A4 and can raise cyclosporine concentrations. Cyclosporine may in turn raise amprenavir levels. The result may be cyclosporine toxicity, including nephrotoxicity.
What this interaction means in plain words
Cyclosporin and Fosamprenavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mutual inhibition of CYP3A4 metabolism, with amprenavir markedly reducing cyclosporine clearance.
What to do
Monitor cyclosporine trough levels frequently and reduce the dose as required. Watch for protease inhibitor adverse effects and monitor renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Fosamprenavir?
MediHelp rates the interaction as major. Cyclosporin and Fosamprenavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amprenavir, the active metabolite of fosamprenavir, inhibits CYP3A4 and can raise cyclosporine concentrations. Cyclosporine may in turn raise amprenavir levels. The result may be cyclosporine toxicity, including nephrotoxicity.
How serious is the interaction between Cyclosporin and Fosamprenavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels frequently and reduce the dose as required. Watch for protease inhibitor adverse effects and monitor renal function.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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