Drug interactions
Cyclosporin + Glecaprevir / pibrentasvir
Severity: Major
Cyclosporin and Glecaprevir / pibrentasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine increases glecaprevir and pibrentasvir exposure, particularly at higher doses. This raises the risk of hepatic adverse effects of the antiviral regimen.
What this interaction means in plain words
Cyclosporin and Glecaprevir / pibrentasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cyclosporine inhibits P-glycoprotein, BCRP, OATP and CYP3A4, increasing glecaprevir and pibrentasvir concentrations.
What to do
Do not coadminister when cyclosporine exceeds 100 mg/day. At lower doses, monitor liver tests and for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as major. Cyclosporin and Glecaprevir / pibrentasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine increases glecaprevir and pibrentasvir exposure, particularly at higher doses. This raises the risk of hepatic adverse effects of the antiviral regimen.
How serious is the interaction between Cyclosporin and Glecaprevir / pibrentasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister when cyclosporine exceeds 100 mg/day. At lower doses, monitor liver tests and for adverse effects.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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