Drug interactions
Cyclosporin + Glibenclamide
Severity: Moderate
Cyclosporin and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may raise glyburide exposure and increase the risk of hypoglycemia. Glyburide may also modestly affect cyclosporine concentrations. Cyclosporine and glyburide both interact with hepatic uptake transporters.
What this interaction means in plain words
Cyclosporin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Glibenclamide belongs to Endocrine.
Why it happens
Cyclosporine inhibits OATP-mediated hepatic uptake and possibly CYP3A4 metabolism of glyburide.
What to do
Monitor blood glucose closely when the combination is started or stopped and reduce the glyburide dose if hypoglycemia occurs. Consider checking cyclosporine trough levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Cyclosporin with Glibenclamide?
MediHelp rates the interaction as moderate. Cyclosporin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may raise glyburide exposure and increase the risk of hypoglycemia. Glyburide may also modestly affect cyclosporine concentrations. Cyclosporine and glyburide both interact with hepatic uptake transporters.
How serious is the interaction between Cyclosporin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when the combination is started or stopped and reduce the glyburide dose if hypoglycemia occurs. Consider checking cyclosporine trough levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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