Drug interactions
Cyclosporin + Hepatitis a / typhoid vaccine
Severity: Minor
Cyclosporin and Hepatitis a / typhoid vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined hepatitis A and typhoid Vi polysaccharide vaccine is inactivated, so cyclosporin does not create a live-vaccine infection risk. Cyclosporin may blunt the antibody response to both components.
What this interaction means in plain words
Cyclosporin and Hepatitis a / typhoid vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Calcineurin inhibition reduces T-cell-dependent antibody responses to vaccine antigens.
What to do
Vaccinate when travel or exposure is anticipated, ideally with sufficient lead time. Consider checking hepatitis A antibodies after vaccination and maintain food and water precautions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Hepatitis a / typhoid vaccine?
MediHelp rates the interaction as minor. Cyclosporin and Hepatitis a / typhoid vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combined hepatitis A and typhoid Vi polysaccharide vaccine is inactivated, so cyclosporin does not create a live-vaccine infection risk. Cyclosporin may blunt the antibody response to both components.
How serious is the interaction between Cyclosporin and Hepatitis a / typhoid vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when travel or exposure is anticipated, ideally with sufficient lead time. Consider checking hepatitis A antibodies after vaccination and maintain food and water precautions.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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