Drug interactions
Cyclosporin + Hepatitis A vaccine inactivated
Severity: Moderate
Cyclosporin and Hepatitis A vaccine inactivated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from cyclosporine can blunt the antibody response to inactivated vaccines. Patients may therefore have inadequate protection after vaccination. The vaccine is not harmful, but its efficacy may be reduced.
What this interaction means in plain words
Cyclosporin and Hepatitis A vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Hepatitis A vaccine inactivated belongs to Anti Virals.
Why it happens
Calcineurin inhibition suppresses T-cell-dependent antibody responses to vaccination.
What to do
Vaccinate before starting immunosuppression when possible, otherwise vaccinate anyway and check antibody titers, revaccinating if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Cyclosporin with Hepatitis A vaccine inactivated?
MediHelp rates the interaction as moderate. Cyclosporin and Hepatitis A vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression from cyclosporine can blunt the antibody response to inactivated vaccines. Patients may therefore have inadequate protection after vaccination. The vaccine is not harmful, but its efficacy may be reduced.
How serious is the interaction between Cyclosporin and Hepatitis A vaccine inactivated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting immunosuppression when possible, otherwise vaccinate anyway and check antibody titers, revaccinating if the response is inadequate.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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