Drug interactions
Cyclosporin + Human papillomavirus vaccine nonavalent
Severity: Moderate
Cyclosporin and Human papillomavirus vaccine nonavalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may reduce immunogenicity of the HPV vaccine, leaving patients with weaker or shorter protection. The vaccine is non-live, so it can still be given.
What this interaction means in plain words
Cyclosporin and Human papillomavirus vaccine nonavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibitor immunosuppression impairs vaccine-induced immune response.
What to do
Vaccinate before starting cyclosporine when possible. Immunosuppressed patients should receive the full three-dose schedule rather than a reduced schedule.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Human papillomavirus vaccine nonavalent?
MediHelp rates the interaction as moderate. Cyclosporin and Human papillomavirus vaccine nonavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may reduce immunogenicity of the HPV vaccine, leaving patients with weaker or shorter protection. The vaccine is non-live, so it can still be given.
How serious is the interaction between Cyclosporin and Human papillomavirus vaccine nonavalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting cyclosporine when possible. Immunosuppressed patients should receive the full three-dose schedule rather than a reduced schedule.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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