Drug interactions
Cyclosporin + Hydrocortisone
Severity: Moderate
Cyclosporin and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can increase corticosteroid exposure, and corticosteroids may alter cyclosporine concentrations in either direction. This can lead to increased steroid adverse effects or changes in immunosuppression.
What this interaction means in plain words
Cyclosporin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Hydrocortisone belongs to Endocrine.
Why it happens
Cyclosporine inhibits CYP3A4 and P-glycoprotein, reducing corticosteroid clearance; corticosteroids may variably affect cyclosporine metabolism.
What to do
Monitor cyclosporine trough levels and signs of corticosteroid excess such as hyperglycemia and hypertension. Adjust doses based on response and levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Cyclosporin with Hydrocortisone?
MediHelp rates the interaction as moderate. Cyclosporin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can increase corticosteroid exposure, and corticosteroids may alter cyclosporine concentrations in either direction. This can lead to increased steroid adverse effects or changes in immunosuppression.
How serious is the interaction between Cyclosporin and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and signs of corticosteroid excess such as hyperglycemia and hypertension. Adjust doses based on response and levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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