Drug interactions
Cyclosporin + Hydroxyprogesterone caproate
Severity: Minor
Cyclosporin and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins may modestly raise cyclosporine concentrations through reduced metabolism, and both agents can affect liver function. The clinical significance is uncertain.
What this interaction means in plain words
Cyclosporin and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by progestins; the mechanism is not firmly established.
What to do
Monitor cyclosporine trough levels and liver enzymes when hydroxyprogesterone is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Cyclosporin and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins may modestly raise cyclosporine concentrations through reduced metabolism, and both agents can affect liver function. The clinical significance is uncertain.
How serious is the interaction between Cyclosporin and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and liver enzymes when hydroxyprogesterone is started or stopped.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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