Drug interactions
Cyclosporin + Influenza virus vaccine adjuvanted
Severity: Moderate
Cyclosporin and Influenza virus vaccine adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may reduce the antibody response to adjuvanted H5N1 influenza vaccine. Protection may be lower than in immunocompetent people.
What this interaction means in plain words
Cyclosporin and Influenza virus vaccine adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibitor immunosuppression impairs vaccine-induced immune response.
What to do
Vaccinate at least 2 weeks before starting cyclosporine when feasible. Consider serologic assessment or an additional dose in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Influenza virus vaccine adjuvanted?
MediHelp rates the interaction as moderate. Cyclosporin and Influenza virus vaccine adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may reduce the antibody response to adjuvanted H5N1 influenza vaccine. Protection may be lower than in immunocompetent people.
How serious is the interaction between Cyclosporin and Influenza virus vaccine adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before starting cyclosporine when feasible. Consider serologic assessment or an additional dose in high-risk patients.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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