Drug interactions
Cyclosporin + Influenza virus vaccine quadrivalent adjuvanted
Severity: Moderate
Cyclosporin and Influenza virus vaccine quadrivalent adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin suppresses T-cell function and can blunt the antibody response to inactivated vaccines. Patients may have lower seroprotection after vaccination and remain susceptible to influenza. The vaccine is not unsafe, but its benefit may be reduced.
What this interaction means in plain words
Cyclosporin and Influenza virus vaccine quadrivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition impairs T-cell activation and T-dependent antibody responses to vaccine antigens.
What to do
Give the vaccine still, ideally at least 2 weeks before starting immunosuppression when feasible, and do not withhold annual vaccination in patients already on cyclosporin. Consider serologic assessment or revaccination if immune response is doubtful, and reinforce other preventive measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Influenza virus vaccine quadrivalent adjuvanted?
MediHelp rates the interaction as moderate. Cyclosporin and Influenza virus vaccine quadrivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin suppresses T-cell function and can blunt the antibody response to inactivated vaccines. Patients may have lower seroprotection after vaccination and remain susceptible to influenza. The vaccine is not unsafe, but its benefit may be reduced.
How serious is the interaction between Cyclosporin and Influenza virus vaccine quadrivalent adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine still, ideally at least 2 weeks before starting immunosuppression when feasible, and do not withhold annual vaccination in patients already on cyclosporin. Consider serologic assessment or revaccination if immune response is doubtful, and reinforce other preventive measures.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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