Drug interactions
Cyclosporin + Influenza virus vaccine quadrivalent intranasal
Severity: Contraindicated
Cyclosporin and Influenza virus vaccine quadrivalent intranasal: contraindicated interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal influenza vaccine contains live attenuated virus, so it may cause vaccine-virus illness in a patient receiving cyclosporin. The immune response may also be poor.
What this interaction means in plain words
Cyclosporin and Influenza virus vaccine quadrivalent intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Suppression of cell-mediated immunity by calcineurin inhibition permits replication of the live attenuated virus and reduces vaccine response.
What to do
Do not use the intranasal live vaccine in patients on cyclosporin. Give an inactivated injectable influenza vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as contraindicated. Cyclosporin and Influenza virus vaccine quadrivalent intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intranasal influenza vaccine contains live attenuated virus, so it may cause vaccine-virus illness in a patient receiving cyclosporin. The immune response may also be poor.
How serious is the interaction between Cyclosporin and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the intranasal live vaccine in patients on cyclosporin. Give an inactivated injectable influenza vaccine instead.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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