Drug interactions
Cyclosporin + Influenza virus vaccine quadrivalent
Severity: Moderate
Cyclosporin and Influenza virus vaccine quadrivalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can reduce antibody responses to inactivated influenza vaccine in transplant recipients and other treated patients. Vaccination remains worthwhile but protection may be incomplete.
What this interaction means in plain words
Cyclosporin and Influenza virus vaccine quadrivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibitor immunosuppression impairs vaccine-induced immune response.
What to do
Give the inactivated vaccine annually and consider a high-dose or adjuvanted formulation in transplant recipients. Avoid live attenuated intranasal vaccine during cyclosporine therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Influenza virus vaccine quadrivalent?
MediHelp rates the interaction as moderate. Cyclosporin and Influenza virus vaccine quadrivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can reduce antibody responses to inactivated influenza vaccine in transplant recipients and other treated patients. Vaccination remains worthwhile but protection may be incomplete.
How serious is the interaction between Cyclosporin and Influenza virus vaccine quadrivalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine annually and consider a high-dose or adjuvanted formulation in transplant recipients. Avoid live attenuated intranasal vaccine during cyclosporine therapy.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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