Drug interactions
Cyclosporin + Irinotecan liposomal
Severity: Major
Cyclosporin and Irinotecan liposomal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and P-gp and may raise exposure to irinotecan and its active metabolite SN-38, increasing the risk of severe diarrhea and myelosuppression. Cyclosporine also affects UGT1A1 and biliary transporters, which may further affect SN-38.
What this interaction means in plain words
Cyclosporin and Irinotecan liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cyclosporine inhibits CYP3A4, P-gp and biliary transporters, reducing irinotecan and SN-38 clearance.
What to do
Avoid the combination if possible. If necessary, monitor blood counts and diarrhea closely and consider reducing the irinotecan dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Irinotecan liposomal?
MediHelp rates the interaction as major. Cyclosporin and Irinotecan liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits CYP3A4 and P-gp and may raise exposure to irinotecan and its active metabolite SN-38, increasing the risk of severe diarrhea and myelosuppression. Cyclosporine also affects UGT1A1 and biliary transporters, which may further affect SN-38.
How serious is the interaction between Cyclosporin and Irinotecan liposomal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, monitor blood counts and diarrhea closely and consider reducing the irinotecan dose.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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