Drug interactions
Cyclosporin + Isradipine
Severity: Moderate
Cyclosporin and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine and dihydropyridine calcium channel blockers share CYP3A4 metabolism, so blood levels of either may change when combined. Isradipine may cause additive hypotension or peripheral edema, and cyclosporine exposure may rise modestly with some calcium channel blockers. The clinical effect is usually modest.
What this interaction means in plain words
Cyclosporin and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for CYP3A4 and P-glycoprotein-mediated metabolism and transport may raise concentrations of either drug, with additive vasodilatory effects.
What to do
Monitor blood pressure and cyclosporine trough levels when isradipine is started, stopped or adjusted. Adjust the cyclosporine dose according to levels and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Isradipine?
MediHelp rates the interaction as moderate. Cyclosporin and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine and dihydropyridine calcium channel blockers share CYP3A4 metabolism, so blood levels of either may change when combined. Isradipine may cause additive hypotension or peripheral edema, and cyclosporine exposure may rise modestly with some calcium channel blockers. The clinical effect is usually modest.
How serious is the interaction between Cyclosporin and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and cyclosporine trough levels when isradipine is started, stopped or adjusted. Adjust the cyclosporine dose according to levels and renal function.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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