Drug interactions
Cyclosporin + Ixabepilone
Severity: Moderate
Cyclosporin and Ixabepilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixabepilone is cleared mainly by CYP3A4, and cyclosporine is a CYP3A4 and P-gp inhibitor that can raise ixabepilone exposure. Higher levels may worsen neutropenia and peripheral neuropathy.
What this interaction means in plain words
Cyclosporin and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits CYP3A4-mediated metabolism of ixabepilone.
What to do
Prefer an alternative immunosuppressant if possible. If combined, monitor blood counts and neuropathy closely and consider reducing the ixabepilone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Ixabepilone?
MediHelp rates the interaction as moderate. Cyclosporin and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ixabepilone is cleared mainly by CYP3A4, and cyclosporine is a CYP3A4 and P-gp inhibitor that can raise ixabepilone exposure. Higher levels may worsen neutropenia and peripheral neuropathy.
How serious is the interaction between Cyclosporin and Ixabepilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative immunosuppressant if possible. If combined, monitor blood counts and neuropathy closely and consider reducing the ixabepilone dose.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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