Drug interactions
Cyclosporin + Japanese encephalitis virus vaccine
Severity: Moderate
Cyclosporin and Japanese encephalitis virus vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin suppresses T-cell function and can blunt the antibody response to inactivated vaccines. Protection against Japanese encephalitis may therefore be incomplete in treated patients, which matters for travelers to endemic areas.
What this interaction means in plain words
Cyclosporin and Japanese encephalitis virus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition impairs T-cell activation and T-dependent antibody responses to vaccine antigens.
What to do
Vaccinate at least 2 weeks before immunosuppression when possible, and consider checking neutralizing antibody titers or revaccinating if protection is uncertain. Advise strict mosquito-avoidance measures during travel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Japanese encephalitis virus vaccine?
MediHelp rates the interaction as moderate. Cyclosporin and Japanese encephalitis virus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin suppresses T-cell function and can blunt the antibody response to inactivated vaccines. Protection against Japanese encephalitis may therefore be incomplete in treated patients, which matters for travelers to endemic areas.
How serious is the interaction between Cyclosporin and Japanese encephalitis virus vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before immunosuppression when possible, and consider checking neutralizing antibody titers or revaccinating if protection is uncertain. Advise strict mosquito-avoidance measures during travel.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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