Drug interactions
Cyclosporin + Ketorolac
Severity: Major
Cyclosporin and Ketorolac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is a potent NSAID with notable renal effects, and combining it with cyclosporine increases the risk of acute kidney injury. Ketorolac is also contraindicated in patients at risk of renal failure from volume depletion.
What this interaction means in plain words
Cyclosporin and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Ketorolac belongs to Musculoskeletal.
Why it happens
Additive renal vasoconstriction from prostaglandin inhibition and calcineurin inhibition.
What to do
Avoid ketorolac in patients on cyclosporine and choose a non-NSAID analgesic; if it cannot be avoided, monitor serum creatinine closely and limit to a very short course.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Cyclosporin with Ketorolac?
MediHelp rates the interaction as major. Cyclosporin and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac is a potent NSAID with notable renal effects, and combining it with cyclosporine increases the risk of acute kidney injury. Ketorolac is also contraindicated in patients at risk of renal failure from volume depletion.
How serious is the interaction between Cyclosporin and Ketorolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients on cyclosporine and choose a non-NSAID analgesic; if it cannot be avoided, monitor serum creatinine closely and limit to a very short course.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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