Drug interactions
Cyclosporin + Lonapegsomatropin
Severity: Moderate
Cyclosporin and Lonapegsomatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase CYP450 activity and could lower cyclosporine concentrations. This may reduce immunosuppressive efficacy in transplant patients.
What this interaction means in plain words
Cyclosporin and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Lonapegsomatropin belongs to Endocrine.
Why it happens
Growth hormone may induce CYP3A4-mediated metabolism, though the effect is not well characterized.
What to do
Monitor cyclosporine trough levels after starting or stopping lonapegsomatropin and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Cyclosporin with Lonapegsomatropin?
MediHelp rates the interaction as moderate. Cyclosporin and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone may increase CYP450 activity and could lower cyclosporine concentrations. This may reduce immunosuppressive efficacy in transplant patients.
How serious is the interaction between Cyclosporin and Lonapegsomatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels after starting or stopping lonapegsomatropin and adjust the dose accordingly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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