Drug interactions
Cyclosporin + Magnesium chloride
Severity: Moderate
Cyclosporin and Magnesium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine causes renal magnesium wasting and can lead to hypomagnesemia. Low magnesium may aggravate neurotoxicity such as seizures and tremor in transplant patients. Magnesium supplementation is often needed.
What this interaction means in plain words
Cyclosporin and Magnesium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine increases renal magnesium excretion by impairing tubular reabsorption.
What to do
Monitor serum magnesium regularly during cyclosporine therapy and replace as needed. Separate oral magnesium from other oral drugs and watch renal function when supplementing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Magnesium chloride?
MediHelp rates the interaction as moderate. Cyclosporin and Magnesium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine causes renal magnesium wasting and can lead to hypomagnesemia. Low magnesium may aggravate neurotoxicity such as seizures and tremor in transplant patients. Magnesium supplementation is often needed.
How serious is the interaction between Cyclosporin and Magnesium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium regularly during cyclosporine therapy and replace as needed. Separate oral magnesium from other oral drugs and watch renal function when supplementing.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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