Drug interactions
Cyclosporin + Measles mumps rubella and varicella vaccine live
Severity: Contraindicated
Cyclosporin and Measles mumps rubella and varicella vaccine live: contraindicated interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MMRV contains live attenuated viruses including varicella, which may cause serious disseminated vaccine-virus infection in patients on cyclosporin. The vaccine response may also be reduced.
What this interaction means in plain words
Cyclosporin and Measles mumps rubella and varicella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Calcineurin inhibition suppresses cell-mediated immunity and permits uncontrolled replication of live vaccine viruses.
What to do
Do not administer MMRV to patients on cyclosporin. Delay until immunosuppression is stopped for an adequate interval, usually at least 3 months, and obtain specialist advice.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Measles mumps rubella and varicella vaccine live?
MediHelp rates the interaction as contraindicated. Cyclosporin and Measles mumps rubella and varicella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MMRV contains live attenuated viruses including varicella, which may cause serious disseminated vaccine-virus infection in patients on cyclosporin. The vaccine response may also be reduced.
How serious is the interaction between Cyclosporin and Measles mumps rubella and varicella vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not administer MMRV to patients on cyclosporin. Delay until immunosuppression is stopped for an adequate interval, usually at least 3 months, and obtain specialist advice.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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