Drug interactions
Cyclosporin + Meclofenamate
Severity: Major
Cyclosporin and Meclofenamate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can worsen cyclosporin nephrotoxicity by reducing renal blood flow, and may raise cyclosporin concentrations in some patients. This can lead to acute kidney injury, hypertension and fluid retention.
What this interaction means in plain words
Cyclosporin and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of renal prostaglandin synthesis adds to cyclosporin-induced renal vasoconstriction, producing additive nephrotoxicity.
What to do
Avoid the combination if possible and use an alternative analgesic such as paracetamol. If an NSAID is necessary, use the lowest dose for the shortest time and monitor serum creatinine, blood pressure and cyclosporin levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporin and Meclofenamate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Meclofenamate?
MediHelp rates the interaction as major. Cyclosporin and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as meclofenamate can worsen cyclosporin nephrotoxicity by reducing renal blood flow, and may raise cyclosporin concentrations in some patients. This can lead to acute kidney injury, hypertension and fluid retention.
How serious is the interaction between Cyclosporin and Meclofenamate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use an alternative analgesic such as paracetamol. If an NSAID is necessary, use the lowest dose for the shortest time and monitor serum creatinine, blood pressure and cyclosporin levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
