Drug interactions
Cyclosporin + Meningococcal a c y and w polysaccharide tetanus toxoid conjugate vaccine
Severity: Moderate
Cyclosporin and Meningococcal a c y and w polysaccharide tetanus toxoid conjugate vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin can reduce the antibody response to meningococcal conjugate vaccines, which may leave patients with weaker or shorter protection against invasive disease.
What this interaction means in plain words
Cyclosporin and Meningococcal a c y and w polysaccharide tetanus toxoid conjugate vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition impairs T-cell activation and T-dependent antibody responses to vaccine antigens.
What to do
Vaccinate ideally at least 2 weeks before starting immunosuppression, and do not delay vaccination in patients already treated. Consider revaccination or antibody assessment if immune response is doubtful.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Meningococcal a c y and w polysaccharide tetanus toxoid conjugate vaccine?
MediHelp rates the interaction as moderate. Cyclosporin and Meningococcal a c y and w polysaccharide tetanus toxoid conjugate vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin can reduce the antibody response to meningococcal conjugate vaccines, which may leave patients with weaker or shorter protection against invasive disease.
How serious is the interaction between Cyclosporin and Meningococcal a c y and w polysaccharide tetanus toxoid conjugate vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally at least 2 weeks before starting immunosuppression, and do not delay vaccination in patients already treated. Consider revaccination or antibody assessment if immune response is doubtful.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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