Drug interactions
Cyclosporin + Mestranol
Severity: Moderate
Cyclosporin and Mestranol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens like mestranol may reduce cyclosporine metabolism and raise its levels, and cyclosporine may in turn increase estrogen exposure. This can lead to cyclosporine toxicity and increased estrogen-related adverse effects.
What this interaction means in plain words
Cyclosporin and Mestranol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Estrogens inhibit CYP3A4-mediated cyclosporine metabolism, and cyclosporine may raise estrogen exposure via CYP3A4 and P-gp inhibition.
What to do
Monitor cyclosporine trough levels and renal function, and watch for estrogen adverse effects. Consider non-estrogen contraception.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Mestranol?
MediHelp rates the interaction as moderate. Cyclosporin and Mestranol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogens like mestranol may reduce cyclosporine metabolism and raise its levels, and cyclosporine may in turn increase estrogen exposure. This can lead to cyclosporine toxicity and increased estrogen-related adverse effects.
How serious is the interaction between Cyclosporin and Mestranol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function, and watch for estrogen adverse effects. Consider non-estrogen contraception.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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