Drug interactions
Cyclosporin + Mycophenolic acid
Severity: Moderate
Cyclosporin and Mycophenolic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine lowers mycophenolic acid exposure compared with regimens without it. Changing cyclosporine in or out of a regimen can shift MPA levels, affecting efficacy or toxicity.
What this interaction means in plain words
Cyclosporin and Mycophenolic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Mycophenolic acid belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits MRP2-mediated biliary excretion of MPA glucuronide, reducing enterohepatic recirculation.
What to do
Monitor clinical response and consider MPA exposure monitoring when cyclosporine is started, stopped or changed. Adjust the mycophenolate dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolic acid
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Mycophenolic acid?
MediHelp rates the interaction as moderate. Cyclosporin and Mycophenolic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine lowers mycophenolic acid exposure compared with regimens without it. Changing cyclosporine in or out of a regimen can shift MPA levels, affecting efficacy or toxicity.
How serious is the interaction between Cyclosporin and Mycophenolic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider MPA exposure monitoring when cyclosporine is started, stopped or changed. Adjust the mycophenolate dose as needed.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Cholestyramine. The full list is on the Mycophenolic acid page.
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