Drug interactions
Cyclosporin + Nirogacestat
Severity: Major
Cyclosporin and Nirogacestat: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may raise nirogacestat exposure by inhibiting CYP3A4. This may increase diarrhea, hepatotoxicity and other adverse effects.
What this interaction means in plain words
Cyclosporin and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Nirogacestat belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated nirogacestat metabolism by cyclosporine.
What to do
Avoid concomitant use where possible. If it cannot be avoided, follow the labeled nirogacestat dose reduction and monitor liver enzymes and diarrhea.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Nirogacestat
Frequently asked questions
Can I take Cyclosporin with Nirogacestat?
MediHelp rates the interaction as major. Cyclosporin and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine may raise nirogacestat exposure by inhibiting CYP3A4. This may increase diarrhea, hepatotoxicity and other adverse effects.
How serious is the interaction between Cyclosporin and Nirogacestat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible. If it cannot be avoided, follow the labeled nirogacestat dose reduction and monitor liver enzymes and diarrhea.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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