Drug interactions
Cyclosporin + Octreotide
Severity: Moderate
Cyclosporin and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can lower oral cyclosporine absorption and blood concentrations, risking rejection in transplant patients. Reduced levels have been reported after starting octreotide.
What this interaction means in plain words
Cyclosporin and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Octreotide belongs to Endocrine.
Why it happens
Octreotide reduces gastrointestinal absorption of cyclosporine, possibly through reduced motility and secretion.
What to do
Monitor cyclosporine trough concentrations when octreotide is started or stopped and increase the cyclosporine dose if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Cyclosporin with Octreotide?
MediHelp rates the interaction as moderate. Cyclosporin and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can lower oral cyclosporine absorption and blood concentrations, risking rejection in transplant patients. Reduced levels have been reported after starting octreotide.
How serious is the interaction between Cyclosporin and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations when octreotide is started or stopped and increase the cyclosporine dose if levels fall.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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