Drug interactions
Cyclosporin + Ofatumumab sc
Severity: Moderate
Cyclosporin and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and cyclosporine suppresses T-cell function, so using them together may add to overall immunosuppression. This can raise the risk of serious or opportunistic infections.
What this interaction means in plain words
Cyclosporin and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic immunosuppression from B-cell depletion and calcineurin inhibition.
What to do
Monitor patients closely for signs of infection during combined therapy and reassess the need for both agents. When switching from other immunosuppressants, consider their duration of action and residual immune effects before starting ofatumumab.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Ofatumumab sc?
MediHelp rates the interaction as moderate. Cyclosporin and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and cyclosporine suppresses T-cell function, so using them together may add to overall immunosuppression. This can raise the risk of serious or opportunistic infections.
How serious is the interaction between Cyclosporin and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients closely for signs of infection during combined therapy and reassess the need for both agents. When switching from other immunosuppressants, consider their duration of action and residual immune effects before starting ofatumumab.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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