Drug interactions
Cyclosporin + Olutasidenib
Severity: Major
Cyclosporin and Olutasidenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olutasidenib induces CYP3A4 and may lower cyclosporine concentrations. Subtherapeutic levels may cause graft rejection or loss of efficacy.
What this interaction means in plain words
Cyclosporin and Olutasidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Olutasidenib belongs to Oncology.
Why it happens
Induction of CYP3A4 by olutasidenib increases cyclosporine metabolism.
What to do
Avoid if possible. If unavoidable, monitor cyclosporine trough levels and increase the dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Olutasidenib
Frequently asked questions
Can I take Cyclosporin with Olutasidenib?
MediHelp rates the interaction as major. Cyclosporin and Olutasidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olutasidenib induces CYP3A4 and may lower cyclosporine concentrations. Subtherapeutic levels may cause graft rejection or loss of efficacy.
How serious is the interaction between Cyclosporin and Olutasidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, monitor cyclosporine trough levels and increase the dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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