Drug interactions
Cyclosporin + Oxandrolone
Severity: Moderate
Cyclosporin and Oxandrolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens and anabolic steroids have been reported to raise cyclosporine concentrations. This may increase nephrotoxicity, and 17-alpha-alkylated steroids add hepatotoxic potential.
What this interaction means in plain words
Cyclosporin and Oxandrolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable inhibition of cyclosporine metabolism, with additive hepatotoxicity.
What to do
Monitor cyclosporine trough levels, serum creatinine and liver tests, and adjust the cyclosporine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Oxandrolone?
MediHelp rates the interaction as moderate. Cyclosporin and Oxandrolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens and anabolic steroids have been reported to raise cyclosporine concentrations. This may increase nephrotoxicity, and 17-alpha-alkylated steroids add hepatotoxic potential.
How serious is the interaction between Cyclosporin and Oxandrolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels, serum creatinine and liver tests, and adjust the cyclosporine dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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