Drug interactions
Cyclosporin + Paltusotine
Severity: Major
Cyclosporin and Paltusotine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paltusotine may reduce cyclosporine bioavailability, risking subtherapeutic levels. In transplant or autoimmune patients this can lead to rejection or loss of disease control.
What this interaction means in plain words
Cyclosporin and Paltusotine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Paltusotine belongs to Endocrine.
Why it happens
Paltusotine reduces cyclosporine absorption, probably via effects on gastrointestinal function or transport; the exact mechanism is not fully established.
What to do
Monitor cyclosporine trough concentrations closely after starting or stopping paltusotine and adjust the cyclosporine dose accordingly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Paltusotine?
MediHelp rates the interaction as major. Cyclosporin and Paltusotine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Paltusotine may reduce cyclosporine bioavailability, risking subtherapeutic levels. In transplant or autoimmune patients this can lead to rejection or loss of disease control.
How serious is the interaction between Cyclosporin and Paltusotine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations closely after starting or stopping paltusotine and adjust the cyclosporine dose accordingly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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